袁圓

上海市第一人民醫(yī)院麻醉科主治醫(yī)師

參與基金項(xiàng)目

1、國家自然科學(xué)基金委員會(huì), 青年科學(xué)基金項(xiàng)目（C類）轉(zhuǎn)錄因子KLF14乳?；揎椩谀摱景Y巨噬細(xì)胞免疫功能障礙中的作用及機(jī)制研究, 2024-01-01 至 2026-12-31, 30 萬元,在研, 主持；

2、國家自然科學(xué)基金委員會(huì), 面上項(xiàng)目,HK2 乳?；揎椊閷?dǎo)巨噬細(xì)胞 功能障礙在膿毒癥中的作用及機(jī)制, 2024-01-01 至 2027-12-31, 49 萬元, 在研, 參與。

發(fā)表文章

1. Yuan Yuan, Guangjian Fan, Yuqi Liu et al. The transcription factor KLF14 regulates macrophage glycolysis and immune function by inhibiting HK2 in sepsis. Cell Mol Immunol, 2022, 19: 0.

2. Lu Liu, Yuan Yuan,Yu Zhou et al. The transcription factor KLF14 attenuates LPS-induced acute lung injury by ameliorating apoptosis of alveolar epithelial cells in mice. Mol Immunol, 2022, 152: 0.

3. Yu, Zhou, Yuan, Yuan,Xuanqi, Yao et al. miPEP31 alleviates sepsis development by regulating Chi3l1-dependent macrophage polarization.[J] .Biol Direct, 2024, 19: 0.

4. Liu Y, Wang L, Zhou C, Yuan Y, Fang B, Lu K, Xu F, Chen L, Huang L. MiR-31-5p regulates the neuroinflammatory response via TRAF6 in neuropathic pain. Biol Direct. 2024 Jan 24;19(1).

5. Luo S, Lyu Z, Ge L, Li Y, Liu Y, Yuan Y, Zhao R, Huang L, Zhao J, Huang H, Luo Y. ATAXIA TELANGIECTASIA MUTATED PROTECTS AGAINST LIPOPOLYSACCARIDE-INDUCED BLOOD-BRAIN BARRIER DISRUPTION BY REGULATING ATK/DRP1-MEDIATED MITOCHONDRIAL HOMEOSTASIS. Shock. 2023 Jul 1;60(1):100-109.

6. Zhuochen Lyu , Shiyuan Luo , Yinjiao Li , Liangfang Yao , Feng Chen , Qing Tu , Yuan Yuan , Jinbao Li , Yan Luo. Neuronal SIRT3 Decline Mediates Sepsis-Associated Encephalopathy through Microglia Activation. Journal of Biological Regulators and Homeostatic Agents. 2024, 38(2): 1139-1152.

7. Tu Q, Li Y, Zhu J, Guo L, Liu C, Liu L, Yuan Y, Zou Y, Chen F, Yao L, Li J. Mitochondrial DNA mediates immunoparalysis of dendritic cells in sepsis via STING signalling. Cell Prolif. 2022 Dec;55(12):e13328.

8. Tu Q, Zhu Y, Yuan Y, Guo L, Liu L, Yao L, Zou Y, Li J, Chen F. Gypenosides Inhibit Inflammatory Response and Apoptosis of Endothelial and Epithelial Cells in LPS-Induced ALI: A Study Based on Bioinformatic Analysis and in vivo/vitro Experiments. Drug Des Devel Ther. 2021 Jan 25;15:289-303.

9. 《感染性休克復(fù)蘇液體的選擇和指導(dǎo)液體治療的監(jiān)測指標(biāo)》（嶺南現(xiàn) 代臨床外科，第一作者）

10. 《不同濃度的鹽酸甲哌卡因在下肢手術(shù)患者腰叢阻滯中的應(yīng)用》（嶺 南現(xiàn)代臨床外科，第一作者）